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Context: Primary care physicians report high levels of distress, which is linked to burnout, attrition, and poorer quality of care. Programs to reduce burnout before it results in impairment are rare; data on these programs are scarce.
Objective: To determine whether an intensive educational program in mindfulness, communication, and self-awareness is associated with improvement in primary care physicians' well-being, psychological distress, burnout, and capacity for relating to patients.
Results: Over the course of the program and follow-up, participants demonstrated improvements in mindfulness (raw score, 45.2 to 54.1; raw score change [Delta], 8.9; 95% confidence interval [CI], 7.0 to 10.8); burnout (emotional exhaustion, 26.8 to 20.0; Delta = -6.8; 95% CI, -4.8 to -8.8; depersonalization, 8.4 to 5.9; Delta = -2.5; 95% CI, -1.4 to -3.6; and personal accomplishment, 40.2 to 42.6; Delta = 2.4; 95% CI, 1.2 to 3.6); empathy (116.6 to 121.2; Delta = 4.6; 95% CI, 2.2 to 7.0); physician belief scale (76.7 to 72.6; Delta = -4.1; 95% CI, -1.8 to -6.4); total mood disturbance (33.2 to 16.1; Delta = -17.1; 95% CI, -11 to -23.2), and personality (conscientiousness, 6.5 to 6.8; Delta = 0.3; 95% CI, 0.1 to 5 and emotional stability, 6.1 to 6.6; Delta = 0.5; 95% CI, 0.3 to 0.7). Improvements in mindfulness were correlated with improvements in total mood disturbance (r = -0.39, P < .001), perspective taking subscale of physician empathy (r = 0.31, P < .001), burnout (emotional exhaustion and personal accomplishment subscales, r = -0.32 and 0.33, respectively; P < .001), and personality factors (conscientiousness and emotional stability, r = 0.29 and 0.25, respectively; P < .001).
Conclusions: Participation in a mindful communication program was associated with short-term and sustained improvements in well-being and attitudes associated with patient-centered care. Because before-and-after designs limit inferences about intervention effects, these findings warrant randomized trials involving a variety of practicing physicians.
The therapeutic landscape for Acute Myeloid Leukemia (AML) patients has undergone a remarkable transformation in the past five years. The addition of small molecule inhibitors, such as BCL-2, IDH, and FLT3 inhibitors, have led to increased treatment options and improved outcomes for many patients. However, despite these advancements, the majority of patients will not be cured of their disease. Measurable residual disease (MRD) testing in remission after treatment for AML can identify patients at increased risk of relapse and death. There are also ongoing efforts investigating novel therapeutics for high-risk AML patient subsets to improve current unacceptable poor outcomes. This educational session will examine the current evidence for integrating MRD into response assessments and as a potential treatment goal for patients. The session will also discuss ongoing investigational efforts to improve outcomes in high-risk AML patient subsets such as secondary AML and the genomic subsets: MLL rearranged, FLT3-ITD and TP53 mutated.
Myeloproliferative neoplasms (MPNs), including essential thrombocytosis (ET), polycythemia vera (PV), and myelofibrosis (MF) are hematopoietic stem cell neoplasms with heterogeneous clinical features and outcomes, but a common pathogenic driver: JAK/STAT pathway activation. Despite the development of JAK pathway inhibitors, many clinical challenges and unmet needs persist in the MPN field. This educational sess