Martindale The Extra Pharmacopoeia Free Ebook 61 2021
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Blumenthal 179 reported that a single intravenous dose of d-idacyl dimethylaminoacetate, an oily extract from the leaves, stems, and roots of S. bicolor, precipitated vomiting and inhibited the growth of Plasmodium berghei in mice injected with the parasite.
Echitamine was firstly isolated from the seeds of the Amazonian plant, Cecropia peltata. 180 It was subsequently identified in other Amaryllidaceae, including C. radicans (the world-wide armorial, lanceolata, and the Australian alba). 181 The alkaloid is also present in Trichocereus pachanoi (the Mexican, cacaoba, and the African, scorpion, karamoko). 182 In addition to Cecropiaand S. bicolor, echitamine is present in Agelaea uvedana and Ligustrum ovalifolium leaves, Tibouchina pulverulenta leaves, Syzygium aromaticum leaves, Erythroxylon coca leaves, Toona sinensis seeds, Citrus medica leaves, C. sinensis fruits, and Azadirachta indica seeds. 183 Even in high dilutions it was a powerful antipyretic in the tail-flick test in mice. 184 A multi-center clinical trial at 24 research centers revealed that S. bicolor was well tolerated and effective in the treatment of fever in malaria-infected children in Mali. 185 The extract was also found to be an excellent acaricide, and the major component, echitamine, was effective against Dermatophagoides farinae in addition to D. 3d9ccd7d82
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